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How Effective Are Weight Loss Drugs? Weight loss drugs don’t always work for everyone, diet pills that start with an a. It is usually recommended that one to two pounds of weight can be safely lost per week. Weight loss drugs typically result in a 5% to 10% weight loss over a 12-month period when used as part of a diet and exercise plan. For a patient weighing 200 pounds, this would translate into losing about 10 to 20 pounds over one year, which would fall within the safe guidelines for weight loss.
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